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HSP90B1 / GP96 / GRP94 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - HSP90B1 / GP96 / GRP94 Antibody ALS12912
    Anti-HSP90B1 / GRP94 antibody IHC of human small intestine.
    detail
  • WB - HSP90B1 / GP96 / GRP94 Antibody ALS12912
    Lane 1: MW Marker, Lane 2: Rat Brain Extract, Lane 3: Mouse Brain Extract, Lane 4: Rat Liver...
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IP
Primary Accession P14625
Reactivity Human, Mouse, Rat, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 92kDa
Dilution IHC-P (10 µg/ml), IP (1:80), WB (1:1000)
Additional Information
Gene ID 7184
Other Names Endoplasmin, 94 kDa glucose-regulated protein, GRP-94, Heat shock protein 90 kDa beta member 1, Tumor rejection antigen 1, gp96 homolog, HSP90B1, GRP94, TRA1
Reconstitution & Storage Store at -20°C.
PrecautionsHSP90B1 / GP96 / GRP94 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HSP90B1 (HGNC:12028)
Function Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (PubMed:18264092). Has ATPase activity (By similarity). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum- Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059).
Cellular Location Endoplasmic reticulum lumen. Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:P41148}. Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Research Areas
Citations (0)
citation

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Background

Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.

References

Maki R.G.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:5658-5662(1990).
Chang S.C.,et al.Mol. Cell. Biol. 9:2153-2162(1989).
Meng S.,et al.Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
Gevaert K.,et al.Nat. Biotechnol. 21:566-569(2003).
Meunier L.,et al.Mol. Biol. Cell 13:4456-4469(2002).

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$ 467.50
Cat# ALS12912
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