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TUBB / Beta Tubulin Antibody
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF |
|---|---|
| Primary Accession | P07437 |
| Reactivity | Human, Mouse, Rat, Rabbit, Chicken, Bovine |
| Host | Mouse |
| Clonality | Monoclonal |
| Calculated MW | 50kDa |
| Dilution | IHC-P (10 µg/ml), WB (0.5-1 µg/ml), |
| Gene ID | 203068 |
|---|---|
| Other Names | Tubulin beta chain, Tubulin beta-5 chain, TUBB, TUBB5 |
| Target/Specificity | Recognizes human Tubulin, beta. Species cross-reactivity: Bovine, rabbit, mouse, chicken, rat, frog, moth and wheat. |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | TUBB / Beta Tubulin Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TUBB |
|---|---|
| Synonyms | TUBB5 |
| Function | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Cellular Location | Cytoplasm, cytoskeleton |
| Tissue Location | Ubiquitously expressed with highest levels in spleen, thymus and immature brain. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
References
Lee M.G.-S.,et al.Cell 33:477-487(1983).
Hall J.L.,et al.Mol. Cell. Biol. 3:854-862(1983).
Crabtree D.V.,et al.Bioorg. Med. Chem. 9:1967-1976(2001).
Yu W.,et al.Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
Shiina S.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
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