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TNFRSF1A / TNFR1 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IP |
|---|---|
| Primary Accession | P19438 |
| Reactivity | Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Sheep, Yeast, Xenopus, Bovine, Dog, Drosophila |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 50kDa |
| Dilution | IHC-P (10 µg/ml), IP (12.5 µg/ml), WB (1:1000) |
| Gene ID | 7132 |
|---|---|
| Other Names | Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor 1, TNF-R1, Tumor necrosis factor receptor type I, TNF-RI, TNFR-I, p55, p60, CD120a, Tumor necrosis factor receptor superfamily member 1A, membrane form, Tumor necrosis factor-binding protein 1, TBPI, TNFRSF1A, TNFAR, TNFR1 |
| Reconstitution & Storage | Store at -20°C. Aliquot to avoid freeze/thaw cycles. |
| Precautions | TNFRSF1A / TNFR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TNFRSF1A |
|---|---|
| Synonyms | TNFAR, TNFR1 |
| Function | Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein Golgi apparatus membrane; Single-pass type I membrane protein. Secreted. Note=A secreted form is produced through proteolytic processing |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
References
Loetscher H.,et al.Cell 61:351-359(1990).
Schall T.J.,et al.Cell 61:361-370(1990).
Himmler A.,et al.DNA Cell Biol. 9:705-715(1990).
Nophar Y.,et al.EMBO J. 9:3269-3278(1990).
Gray P.W.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:7380-7384(1990).
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