ID3 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | Q02535 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 13kDa |
Dilution | IHC-P (10 µg/ml) |
Gene ID | 3399 |
---|---|
Other Names | DNA-binding protein inhibitor ID-3, Class B basic helix-loop-helix protein 25, bHLHb25, Helix-loop-helix protein HEIR-1, ID-like protein inhibitor HLH 1R21, Inhibitor of DNA binding 3, Inhibitor of differentiation 3, ID3, 1R21, BHLHB25, HEIR1 |
Reconstitution & Storage | Store at 2°C to 8°C degrees. Do not freeze. |
Precautions | ID3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ID3 |
---|---|
Synonyms | 1R21, BHLHB25, HEIR1 |
Function | Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. |
Cellular Location | Nucleus. |
Tissue Location | Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain |
Volume | 500 µl |
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Background
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.
References
Ellmeier W.,et al.EMBO J. 11:2563-2571(1992).
Deed R.W.,et al.Oncogene 8:599-607(1993).
Deed R.W.,et al.Gene 151:309-314(1994).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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