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BAK1 / BAK Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - BAK1 / BAK Antibody (N-Terminus) ALS12773
    Anti-BAK1 / BAK antibody IHC of human colon.
    detail
  • IHC - BAK1 / BAK Antibody (N-Terminus) ALS12773
    Anti-BAK1 / BAK antibody IHC of human skeletal muscle.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
  • detail
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q16611
Reactivity Human, Mouse, Hamster
Host Rabbit
Clonality Polyclonal
Calculated MW 23kDa
Dilution IHC-P (1:300)
Additional Information
Gene ID 578
Other Names Bcl-2 homologous antagonist/killer, Apoptosis regulator BAK, Bcl-2-like protein 7, Bcl2-L-7, BAK1, BAK, BCL2L7, CDN1
Reconstitution & Storage Store at 2°C to 8°C degrees. Do not freeze.
PrecautionsBAK1 / BAK Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BAK1
Synonyms BAK, BCL2L7, CDN1
Function Plays a role in the mitochondrial apoptotic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases.
Cellular Location Mitochondrion outer membrane; Single-pass membrane protein
Tissue Location Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle
Volume 250 µl
Research Areas
Citations (0)
citation

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Background

In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.

References

Farrow S.N.,et al.Nature 374:731-733(1995).
Chittenden T.,et al.Nature 374:733-736(1995).
Kiefer M.C.,et al.Nature 374:736-739(1995).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).

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$ 467.50
Cat# ALS12773
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