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MAdCAM-1 Antibody (clone 314G8, Low Endotoxin)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E, FC |
|---|---|
| Primary Accession | Q13477 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 314G8 |
| Calculated MW | 40kDa |
| Dilution | Flo (1:10-1:100), IHC-P (10 µg/ml), |
| Gene ID | 8174 |
|---|---|
| Other Names | Mucosal addressin cell adhesion molecule 1, MAdCAM-1, hMAdCAM-1, MADCAM1 |
| Target/Specificity | Recognizes human mucosal addressin cell adhesion molecule 1 (MAdCAM-1), a 60kD cell surface protein that is involved in lymphocyte trafficking. MAdCAM-1 is expressed on high endothelial venules of Peyers patches and mesenteric lymph nodes. MAdCAM-1 e ... |
| Reconstitution & Storage | Store at -20°C. Aliquot to avoid freeze/thaw cycles. Store undiluted. |
| Precautions | MAdCAM-1 Antibody (clone 314G8, Low Endotoxin) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MADCAM1 |
|---|---|
| Function | Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7- dependent adhesion strengthening, independent of L-selectin binding. |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Location | Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L- selectin binding.
References
Leung E.,et al.Immunol. Cell Biol. 74:490-496(1996).
Shyjan A.M.,et al.J. Immunol. 156:2851-2857(1996).
Leung E.,et al.Immunogenetics 46:111-119(1997).
Wang P.Z.,et al.Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
Grimwood J.,et al.Nature 428:529-535(2004).
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