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ITPR2 / IP3 Receptor Type 2 Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q14571 |
| Reactivity | Human, Monkey |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 308kDa |
| Dilution | ELISA (1:128000), IHC-P (3.75 µg/ml), |
| Gene ID | 3709 |
|---|---|
| Other Names | Inositol 1, 4, 5-trisphosphate receptor type 2, IP3 receptor isoform 2, IP3R 2, InsP3R2, Type 2 inositol 1, 4, 5-trisphosphate receptor, Type 2 InsP3 receptor, ITPR2 |
| Target/Specificity | Human ITPR2. No cross-reactivity expected with other types of ITPR. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | ITPR2 / IP3 Receptor Type 2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ITPR2 (HGNC:6181) |
|---|---|
| Function | Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long- lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (By similarity). |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Z329}; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q8WN96}; Multi-pass membrane protein. Note=Forms clusters on endoplasmic reticulum membrane upon inositol 1,4,5-trisphosphate binding {ECO:0000250|UniProtKB:Q9Z329} |
| Tissue Location | [Isoform Short]: Found in skeletal muscle and heart. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity).
References
Yamamoto-Hino M.,et al.Recept. Channels 2:9-22(1994).
Futatsugi A.,et al.Biochem. J. 334:559-563(1998).
Scherer S.E.,et al.Nature 440:346-351(2006).
Yang J.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:7711-7716(2002).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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