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CYP19 / Aromatase Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P11511 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 58kDa |
| Dilution | ELISA (1:128000), IHC-P (4 µg/ml), WB (0.1-0.3 µg/ml) |
| Gene ID | 1588 |
|---|---|
| Other Names | Aromatase, 1.14.14.14, CYPXIX, Cytochrome P-450AROM, Cytochrome P450 19A1, Estrogen synthase, CYP19A1, ARO1, CYAR, CYP19 |
| Target/Specificity | Human CYP19A1 / Aromatase. This antibody is expected to recognise both reported isoforms (NP_000094.2 and NP_112503.1), which are identical |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | CYP19 / Aromatase Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CYP19A1 {ECO:0000303|PubMed:24705274, ECO:0000312|HGNC:HGNC:2594} |
|---|---|
| Function | A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively (PubMed:27702664, PubMed:2848247). Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid (PubMed:20385561). Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19- nordihydrotestosterone and may play a role in homeostasis of this potent androgen (PubMed:22773874). Also displays 2-hydroxylase activity toward estrone (PubMed:22773874). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:20385561, PubMed:22773874). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi- pass membrane protein |
| Tissue Location | Widely expressed, including in adult and fetal brain, placenta, skin fibroblasts, adipose tissue and gonads |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
References
Harada N.,et al.Biochem. Biophys. Res. Commun. 156:725-732(1988).
Chen S.,et al.DNA 7:27-38(1988).
Corbin C.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:8948-8952(1988).
Toda K.,et al.FEBS Lett. 247:371-376(1989).
Means G.D.,et al.J. Biol. Chem. 264:19385-19391(1989).
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