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ALK2 / ACVR1 Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - ALK2 / ACVR1 Antibody (Internal) ALS12616
    Antibody (0.3 ug/ml) staining of Human Umbilical Cord lysate (35 ug protein in RIPA buffer).
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q04771
Reactivity Human, Mouse, Rat, Rabbit, Monkey, Pig, Horse, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 57kDa
Dilution ELISA (1:128000), IHC-P (4 µg/ml), WB (0.3-1 µg/ml)
Additional Information
Gene ID 90
Other Names Activin receptor type-1, 2.7.11.30, Activin receptor type I, ACTR-I, Activin receptor-like kinase 2, ALK-2, Serine/threonine-protein kinase receptor R1, SKR1, TGF-B superfamily receptor type I, TSR-I, ACVR1, ACVRLK2
Target/Specificity Human ACVR1 / ALK2.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsALK2 / ACVR1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ACVR1
Synonyms ACVRLK2
Function Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation (PubMed:20628059, PubMed:22977237). As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A or ACVR2B (PubMed:17911401). Upon binding of ligands such as BMP7 or GDF2/BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain (PubMed:25354296). In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal (PubMed:9748228). In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor (PubMed:17911401). Besides canonical SMAD signaling, can activate non-canonical pathways such as p38 mitogen-activated protein kinases/MAPKs (By similarity). May promote the expression of HAMP, potentially via its interaction with BMP6 (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein.
Tissue Location Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells
Research Areas
Citations (0)
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Background

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).

References

Matsuzaki K.,et al.J. Biol. Chem. 268:12719-12723(1993).
ten Dijke P.,et al.Oncogene 8:2879-2887(1993).
Oppermann F.S.,et al.Mol. Cell. Proteomics 8:1751-1764(2009).
Umasankar P.K.,et al.Nat. Cell Biol. 14:488-501(2012).
Shore E.M.,et al.Nat. Genet. 38:525-527(2006).

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$ 467.50
Cat# ALS12616
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