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CPT1A Antibody (Internal)

Goat Polyclonal Antibody

     
  • IHC - CPT1A Antibody (Internal) ALS12614
    Anti-CPT1A antibody IHC of human heart.
    detail
  • IHC - CPT1A Antibody (Internal) ALS12614
    Anti-CPT1A antibody IHC of human kidney.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
  • detail
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P50416
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 88kDa
Dilution ELISA (1:128000), IHC-P (4 µg/ml), WB (0.1-0.3 µg/ml)
Additional Information
Gene ID 1374
Other Names Carnitine O-palmitoyltransferase 1, liver isoform, CPT1-L, 2.3.1.21, Carnitine O-palmitoyltransferase I, liver isoform, CPT I, CPTI-L, Carnitine palmitoyltransferase 1A, CPT1A, CPT1
Target/Specificity Human CPT1A. This antibody is expected to recognize both reported isoforms (NP_001867.2; NP_001027017.1) but is not expected to recognise CPT1B.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsCPT1A Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CPT1A (HGNC:2328)
Synonyms CPT1
Function Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:11350182, PubMed:14517221, PubMed:16651524, PubMed:9691089). Possesses also a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity (PubMed:29425493). Plays an important role in hepatic triglyceride metabolism (By similarity). Plays also a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl- CoA-mediated CPT1A repression (By similarity). Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation (PubMed:38016475). Promotes ROS-induced oxidative stress in liver injury via modulation of NFE2L2 and NLRP3-mediated signaling pathways (By similarity).
Cellular Location Mitochondrion outer membrane; Multi-pass membrane protein
Tissue Location Strong expression in kidney and heart, and lower in liver and skeletal muscle
Research Areas
Citations (0)
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Background

Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism.

References

Britton C.H.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:1984-1988(1995).
Gobin S.,et al.Hum. Genet. 111:179-189(2002).
Kalnine N.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Napal L.,et al.J. Mol. Biol. 354:751-759(2005).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).

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$ 467.50
Cat# ALS12614
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