CPT1A Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | P50416 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 88kDa |
Dilution | ELISA (1:128000), IHC-P (4 µg/ml), WB (0.1-0.3 µg/ml) |
Gene ID | 1374 |
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Other Names | Carnitine O-palmitoyltransferase 1, liver isoform, CPT1-L, 2.3.1.21, Carnitine O-palmitoyltransferase I, liver isoform, CPT I, CPTI-L, Carnitine palmitoyltransferase 1A, CPT1A, CPT1 |
Target/Specificity | Human CPT1A. This antibody is expected to recognize both reported isoforms (NP_001867.2; NP_001027017.1) but is not expected to recognise CPT1B. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | CPT1A Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CPT1A (HGNC:2328) |
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Synonyms | CPT1 |
Function | Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:11350182, PubMed:14517221, PubMed:16651524, PubMed:9691089). Possesses also a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity (PubMed:29425493). Plays an important role in hepatic triglyceride metabolism (By similarity). Plays also a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl- CoA-mediated CPT1A repression (By similarity). Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation (PubMed:38016475). Promotes ROS-induced oxidative stress in liver injury via modulation of NFE2L2 and NLRP3-mediated signaling pathways (By similarity). |
Cellular Location | Mitochondrion outer membrane; Multi-pass membrane protein |
Tissue Location | Strong expression in kidney and heart, and lower in liver and skeletal muscle |
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism.
References
Britton C.H.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:1984-1988(1995).
Gobin S.,et al.Hum. Genet. 111:179-189(2002).
Kalnine N.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Napal L.,et al.J. Mol. Biol. 354:751-759(2005).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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