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HNF4A / HNF4 Antibody (N-Terminus)

Goat Polyclonal Antibody

     
  • IHC - HNF4A / HNF4 Antibody (N-Terminus) ALS12606
    Anti-HNF4A / HNF4 antibody IHC of human small intestine.
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  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P41235
Reactivity Human, Rabbit, Hamster, Monkey, Pig, Horse, Dog
Host Goat
Clonality Polyclonal
Calculated MW 53kDa
Dilution ELISA (1:32000), IHC-P (2 µg/ml), WB (0.1-0.3 µg/ml)
Additional Information
Gene ID 3172
Other Names Hepatocyte nuclear factor 4-alpha, HNF-4-alpha, Nuclear receptor subfamily 2 group A member 1, Transcription factor 14, TCF-14, Transcription factor HNF-4, HNF4A, HNF4, NR2A1, TCF14
Target/Specificity Human HNF4A / HNF4. This antibody is expected to recognise the reported isoforms a, b and c (NP_849180.1; NP_000448.3; NP_849181.1 resp.).
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsHNF4A / HNF4 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HNF4A
Synonyms HNF4, NR2A1, TCF14
Function Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698).
Cellular Location Nucleus.
Research Areas
Citations (0)
citation

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Background

Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1- antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1- alpha. May be essential for development of the liver, kidney and intestine.

References

Kritis A.A.,et al.Gene 173:275-280(1996).
Drewes T.,et al.Mol. Cell. Biol. 16:925-931(1996).
Yamagata K.,et al.Nature 384:458-460(1996).
Tanaka T.,et al.Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
Deloukas P.,et al.Nature 414:865-871(2001).

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$ 467.50
Cat# ALS12606
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