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NR1H2 / LXR Beta Antibody (N-Terminus)

Goat Polyclonal Antibody

     
  • WB - NR1H2 / LXR Beta Antibody (N-Terminus) ALS12601
    Antibody (1 ug/ml) staining of human bone marrow lysate (35 ug protein in RIPA buffer).
    detail
  • IHC - NR1H2 / LXR Beta Antibody (N-Terminus) ALS12601
    Anti-NR1H2 antibody IHC of human spleen.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P55055
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 51kDa
Dilution ELISA (1:64000), IHC-P (3 µg/ml), WB (1-3 µg/ml)
Additional Information
Gene ID 7376
Other Names Oxysterols receptor LXR-beta, Liver X receptor beta, Nuclear receptor NER, Nuclear receptor subfamily 1 group H member 2, Ubiquitously-expressed nuclear receptor, NR1H2, LXRB, NER, UNR
Target/Specificity Human NR1H2. Based on the peptide used, this antibody is expected to be specific for LXR beta and not to cross-react with LXR alpha.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsNR1H2 / LXR Beta Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NR1H2
Synonyms LXRB, NER, UNR
Function Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (By similarity). Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957).
Cellular Location Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
Tissue Location Ubiquitous.
Research Areas
Citations (0)
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Background

Nuclear receptor. Binds preferentially to double- stranded oligonucleotide direct repeats having the consensus half- site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity).

References

Shinar D.M.,et al.Gene 147:273-276(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
Song C.,et al.Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
Farnegardh M.,et al.J. Biol. Chem. 278:38821-38828(2003).

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$ 467.50
Cat# ALS12601
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