F7 / Factor VII Antibody
Sheep Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, E, IP, Neut |
---|---|
Primary Accession | P08709 |
Reactivity | Human |
Host | Sheep |
Clonality | Polyclonal |
Calculated MW | 52kDa |
Dilution | IHC-P (5 µg/ml) |
Gene ID | 2155 |
---|---|
Other Names | Coagulation factor VII, 3.4.21.21, Proconvertin, Serum prothrombin conversion accelerator, SPCA, Eptacog alfa, Factor VII light chain, Factor VII heavy chain, F7 |
Target/Specificity | It is specific for F. VII as determined by immunodiffusion. Identity was established with purified F. VII. |
Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
Precautions | F7 / Factor VII Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | F7 |
---|---|
Function | Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. |
Cellular Location | Secreted. |
Tissue Location | Plasma. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
References
Hagen F.S.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:2412-2416(1986).
O'Hara P.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:5158-5162(1987).
Sabater-Lleal M.,et al.Hum. Genet. 118:741-751(2006).
Soria J.M.,et al.Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
Masroori N.,et al.Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
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