NT5E / eNT / CD73 Antibody (aa27-252, clone 2B6)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | P21589 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 2B6 |
Calculated MW | 63kDa |
Dilution | IHC-P (10 µg/ml), WB (1:1000-1:2000), |
Gene ID | 4907 |
---|---|
Other Names | 5'-nucleotidase, 5'-NT, 3.1.3.5, Ecto-5'-nucleotidase, CD73, NT5E, NT5, NTE |
Reconstitution & Storage | Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles. |
Precautions | NT5E / eNT / CD73 Antibody (aa27-252, clone 2B6) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NT5E |
---|---|
Synonyms | NT5, NTE |
Function | Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside, with AMP being the preferred substrate (PubMed:21933152, PubMed:22997138, PubMed:23142347, PubMed:24887587, PubMed:34403084). Shows a preference for ribonucleotide monophosphates over their equivalent deoxyribose forms (PubMed:34403084). Other substrates include IMP, UMP, GMP, CMP, dAMP, dCMP, dTMP, NAD and NMN (PubMed:21933152, PubMed:22997138, PubMed:23142347, PubMed:24887587, PubMed:34403084). |
Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor |
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Provided below are standard protocols that you may find useful for product applications.
Background
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities.
References
Misumi Y.,et al.Eur. J. Biochem. 191:563-569(1990).
Otsuki T.,et al.DNA Res. 12:117-126(2005).
Mungall A.J.,et al.Nature 425:805-811(2003).
Hansen K.R.,et al.Gene 167:307-312(1995).
Zanoni L.,et al.Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
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