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MKP-1 / DUSP1 Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P28562 |
| Reactivity | Human, Rabbit, Monkey, Pig, Chicken, Horse, Bovine, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 39kDa |
| Dilution | ELISA (1:32000), IHC-P (3.75 µg/ml), WB (0.3-1 µg/ml) |
| Gene ID | 1843 |
|---|---|
| Other Names | Dual specificity protein phosphatase 1, 3.1.3.16, 3.1.3.48, Dual specificity protein phosphatase hVH1, Mitogen-activated protein kinase phosphatase 1, MAP kinase phosphatase 1, MKP-1, Protein-tyrosine phosphatase CL100, DUSP1, CL100, MKP1, PTPN10, VH1 |
| Target/Specificity | Human DUSP1. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | MKP-1 / DUSP1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DUSP1 (HGNC:3064) |
|---|---|
| Function | Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q91790}. |
| Tissue Location | Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.
References
Keyes S.M.,et al.Nature 359:644-647(1992).
Kwak S.P.,et al.J. Biol. Chem. 269:3596-3604(1994).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Van Damme P.,et al.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
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