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LL37 / Cathelicidin Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | P49913 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 19kDa |
| Dilution | IHC-P (5 µg/ml), WB (1 µg/ml), |
| Gene ID | 820 |
|---|---|
| Other Names | Cathelicidin antimicrobial peptide, 18 kDa cationic antimicrobial protein, CAP-18, hCAP-18, Antibacterial protein FALL-39, FALL-39 peptide antibiotic, Antibacterial protein LL-37, CAMP, CAP18, FALL39 |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | LL37 / Cathelicidin Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CAMP (HGNC:1472) |
|---|---|
| Function | Antimicrobial protein that is an integral component of the innate immune system (PubMed:14978112, PubMed:16637646, PubMed:18818205, PubMed:22879591, PubMed:9736536). Binds to bacterial lipopolysaccharides (LPS) (PubMed:16637646, PubMed:18818205). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). Postsecretory processing generates multiple cathelicidin antimicrobial peptides with various lengths which act as a topical antimicrobial defense in sweat on skin (PubMed:14978112). The unprocessed precursor form, cathelicidin antimicrobial peptide, inhibits the growth of Gram-negative E.coli and E.aerogenes with efficiencies comparable to that of the mature peptide LL-37 (in vitro) (PubMed:9736536). |
| Cellular Location | Secreted. Vesicle. Note=Stored as pro-peptide in granules and phagolysosomes of neutrophils (PubMed:7529412, PubMed:9736536). Secreted in sweat onto skin (PubMed:14978112). |
| Tissue Location | Expressed in neutrophilic granulocytes (at protein level) (PubMed:7529412, PubMed:7615076, PubMed:7890387, PubMed:8681941, PubMed:8946956, PubMed:9736536). Expressed in bone marrow (PubMed:7890387). [Antibacterial peptide FALL-39]: Expressed in bone marrow and testis. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.
References
Agerberth B.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:195-199(1995).
Cowland J.B.,et al.FEBS Lett. 368:173-176(1995).
Larrick J.W.,et al.Infect. Immun. 63:1291-1297(1995).
Larrick J.W.,et al.FEBS Lett. 398:74-80(1996).
Gudmundsson G.H.,et al.Eur. J. Biochem. 238:325-332(1996).
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