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GPX1 / Glutathione Peroxidase Antibody (clone 13B2AF)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E, IP |
|---|---|
| Primary Accession | P07203 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 13B2AF |
| Calculated MW | 22kDa |
| Dilution | IHC-P (1:50), WB (1:5000), |
| Gene ID | 2876 |
|---|---|
| Other Names | Glutathione peroxidase 1, GPx-1, GSHPx-1, 1.11.1.9, Cellular glutathione peroxidase, GPX1 |
| Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
| Precautions | GPX1 / Glutathione Peroxidase Antibody (clone 13B2AF) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPX1 (HGNC:4553) |
|---|---|
| Function | Catalyzes the reduction of hydroperoxides in a glutathione- dependent manner thus regulating cellular redox homeostasis (PubMed:11115402, PubMed:36608588). Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides (PubMed:11115402, PubMed:36608588). In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway (PubMed:11115402). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P11352}. Mitochondrion {ECO:0000250|UniProtKB:P11352} |
| Tissue Location | Expressed in platelets (at protein level). |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Protects the hemoglobin in erythrocytes from oxidative breakdown.
References
Sukenaga Y.,et al.Nucleic Acids Res. 15:7178-7178(1987).
Ishida K.,et al.Nucleic Acids Res. 15:10051-10051(1987).
Mullenbach G.T.,et al.Nucleic Acids Res. 15:5484-5484(1987).
Chada S.,et al.Genomics 6:268-271(1990).
Moscow J.A.,et al.J. Biol. Chem. 267:5949-5958(1992).
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