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AIF1 / IBA1 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - AIF1 / IBA1 Antibody (C-Terminus) ALS12364
    Anti-AIF1 / IBA1 antibody IHC of human lung.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P55008
Reactivity Human, Mouse, Rat, Hamster, Monkey, Pig
Host Goat
Clonality Polyclonal
Calculated MW 17kDa
Dilution ELISA (1:128000), IHC-P (5 µg/ml), WB (1-3 µg/ml)
Additional Information
Gene ID 199
Other Names Allograft inflammatory factor 1, AIF-1, Ionized calcium-binding adapter molecule 1, Protein G1, AIF1, G1, IBA1
Target/Specificity Human AIF1 / IBA1. This antibody is expected to recognize isoform 1 (NP_116573.1) and isoform 3 (NP_001614.3).
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsAIF1 / IBA1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AIF1
Synonyms G1, IBA1
Function Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
Cellular Location Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O70200}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:O70200}; Peripheral membrane protein {ECO:0000250|UniProtKB:O70200}; Cytoplasmic side {ECO:0000250|UniProtKB:O70200}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:O70200}. Note=Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis {ECO:0000250|UniProtKB:O70200}
Tissue Location Detected in T-lymphocytes and peripheral blood mononuclear cells.
Research Areas
Citations (0)
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Background

Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.

References

Albertella M.R.,et al.Hum. Mol. Genet. 3:793-799(1994).
Holzinger I.,et al.Immunogenetics 42:315-322(1995).
Autieri M.V.,et al.Biochem. Biophys. Res. Commun. 228:29-37(1996).
Utans U.,et al.Transplantation 61:1387-1392(1996).
de Baey A.,et al.Genomics 45:591-600(1997).

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$ 467.50
Cat# ALS12364
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