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Kinesin Heavy Chain / KIF5B Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P33176 |
| Reactivity | Human, Rabbit, Monkey, Pig, Bovine, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 110kDa |
| Dilution | ELISA (1:32000), IHC-P (2.5 µg/ml), WB (0.2-1 µg/ml) |
| Gene ID | 3799 |
|---|---|
| Other Names | Kinesin-1 heavy chain, Conventional kinesin heavy chain, Ubiquitous kinesin heavy chain, UKHC, KIF5B, KNS, KNS1 |
| Target/Specificity | Human KIF5B. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | Kinesin Heavy Chain / KIF5B Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KIF5B (HGNC:6324) |
|---|---|
| Synonyms | KNS, KNS1 |
| Function | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2- dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q2PQA9}. Cytolytic granule membrane. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side Note=Uniformly distributed between soma and neurites in hippocampal neurons. {ECO:0000250|UniProtKB:Q2PQA9} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes.
References
Navone F.,et al.J. Cell Biol. 117:1263-1275(1992).
Deloukas P.,et al.Nature 429:375-381(2004).
Su Q.,et al.Nat. Cell Biol. 6:941-953(2004).
Boucrot E.,et al.Science 308:1174-1178(2005).
Olsen J.V.,et al.Cell 127:635-648(2006).
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