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TH / Tyrosine Hydroxylase Antibody (phospho-Ser40)

Rabbit Polyclonal Antibody

     
  • WB - TH / Tyrosine Hydroxylase Antibody (phospho-Ser40) ALS12276
    Western blot of recombinant phospho- and dephospho-TH showing selective immunolabeling by the...
    detail
  • IHC - TH / Tyrosine Hydroxylase Antibody (phospho-Ser40) ALS12276
    Anti-TH / Tyrosine Hydroxylase antibody IHC of human adrenal.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, IHC-F
Primary Accession P07101
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 59kDa
Dilution IF (1:1000), IHC-Fr (1:1000), IHC-P (5 µg/ml), WB (1:1000) ,
Additional Information
Gene ID 7054
Other Names Tyrosine 3-monooxygenase, 1.14.16.2, Tyrosine 3-hydroxylase, TH, TH, TYH
Target/Specificity Specific for the ~60k tyrosine hydroxylase protein phosphorylated at Ser40. Some higher molecular weight bands may be detected by the antibody depending upon the brain region being studied, protein loads and the detection methods used. The antibody h ...
Reconstitution & Storage Long term: -80°C; Short term: -20°C
PrecautionsTH / Tyrosine Hydroxylase Antibody (phospho-Ser40) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TH (HGNC:11782)
Synonyms TYH
Function Catalyzes the conversion of L-tyrosine to L- dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of cathecolamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (PubMed:15287903, PubMed:1680128, PubMed:17391063, PubMed:24753243, PubMed:34922205, PubMed:8528210, Ref.18). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity (By similarity). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity).
Cellular Location Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P24529}. Nucleus {ECO:0000250|UniProtKB:P04177} Cell projection, axon {ECO:0000250|UniProtKB:P24529}. Cytoplasm {ECO:0000250|UniProtKB:P04177}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:P04177}. Note=When phosphorylated at Ser-19 shows a nuclear distribution and when phosphorylated at Ser-31 as well at Ser-40 shows a cytosolic distribution (By similarity). Expressed in dopaminergic axons and axon terminals. {ECO:0000250|UniProtKB:P04177}
Tissue Location Mainly expressed in the brain and adrenal glands.
Research Areas
Citations (0)
citation

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Background

Plays an important role in the physiology of adrenergic neurons.

References

Kaneda N.,et al.Biochem. Biophys. Res. Commun. 146:971-975(1987).
Grima B.,et al.Nature 326:707-711(1987).
Kobayashi K.,et al.Nucleic Acids Res. 15:6733-6733(1987).
Kobayashi K.,et al.J. Biochem. 103:907-912(1988).
Roma J.,et al.Biol. Chem. 388:419-426(2007).

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$ 467.50
Cat# ALS12276
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