PC / Pyruvate Carboxylase Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | P11498 |
Reactivity | Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Horse, Bovine, Dog |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 130kDa |
Dilution | ELISA (1:16000), IHC-P (5 µg/ml), WB (0.03-0.1 µg/ml) |
Gene ID | 5091 |
---|---|
Other Names | Pyruvate carboxylase, mitochondrial, 6.4.1.1, Pyruvic carboxylase, PCB, PC |
Target/Specificity | Human PC / Pyruvate Carboxylase. All reported variants (NP_000911.2; NP_001035806.1; NP_071504.2) represent identical protein. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | PC / Pyruvate Carboxylase Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PC (HGNC:8636) |
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Function | Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. |
Cellular Location | Mitochondrion matrix |
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Provided below are standard protocols that you may find useful for product applications.
Background
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
References
Wexler I.D.,et al.Biochim. Biophys. Acta 1227:46-52(1994).
Mackay N.,et al.Biochem. Biophys. Res. Commun. 202:1009-1014(1994).
Walker M.E.,et al.Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).
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