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CD34 Antibody (clone MEC14.7)
Rat Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IP, FC |
|---|---|
| Primary Accession | P28906 |
| Reactivity | Human, Mouse |
| Host | Rat |
| Clonality | Monoclonal |
| Clone Names | MEC14.7 |
| Calculated MW | 41kDa |
| Dilution | Flo (1:25-1:50), IHC-P (10 µg/ml), IP (2-10 µg/ml) |
| Gene ID | 947 |
|---|---|
| Other Names | Hematopoietic progenitor cell antigen CD34, CD34, CD34 |
| Target/Specificity | Recognizes the mouse CD34 cell surface glycoprotein. mouse CD34 is expressed by hematopoietic progenitor cells in the bone marrow and also by endothelial cells. |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | CD34 Antibody (clone MEC14.7) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CD34 |
|---|---|
| Function | Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Location | Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.
References
Simmons D.L.,et al.J. Immunol. 148:267-271(1992).
Satterthwaite A.B.,et al.Genomics 12:788-794(1992).
Nakamura Y.,et al.Exp. Hematol. 21:236-242(1993).
Freund D.,et al.Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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