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AIF1 / IBA1 Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P55008 |
| Reactivity | Human, Pig, Horse, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 17kDa |
| Dilution | ELISA (1:32000), IHC-P (2.5 µg/ml), WB (1:32000) |
| Gene ID | 199 |
|---|---|
| Other Names | Allograft inflammatory factor 1, AIF-1, Ionized calcium-binding adapter molecule 1, Protein G1, AIF1, G1, IBA1 |
| Target/Specificity | Human AIF1 / IBA1. This antibody is expected to recognise isoform 3 (NP_001614.3) only. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | AIF1 / IBA1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AIF1 |
|---|---|
| Synonyms | G1, IBA1 |
| Function | Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O70200}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:O70200}; Peripheral membrane protein {ECO:0000250|UniProtKB:O70200}; Cytoplasmic side {ECO:0000250|UniProtKB:O70200}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:O70200}. Note=Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis {ECO:0000250|UniProtKB:O70200} |
| Tissue Location | Detected in T-lymphocytes and peripheral blood mononuclear cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
References
Albertella M.R.,et al.Hum. Mol. Genet. 3:793-799(1994).
Holzinger I.,et al.Immunogenetics 42:315-322(1995).
Autieri M.V.,et al.Biochem. Biophys. Res. Commun. 228:29-37(1996).
Utans U.,et al.Transplantation 61:1387-1392(1996).
de Baey A.,et al.Genomics 45:591-600(1997).
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