OGG1 Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | O15527 |
Reactivity | Human, Mouse |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 39kDa |
Dilution | ELISA (1:128000), IHC-P (2.5 µg/ml), WB (1:128000) |
Gene ID | 4968 |
---|---|
Other Names | N-glycosylase/DNA lyase, 8-oxoguanine DNA glycosylase, 3.2.2.-, DNA-(apurinic or apyrimidinic site) lyase, AP lyase, 4.2.99.18, OGG1, MMH, MUTM, OGH1 |
Target/Specificity | Mouse OGG1. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | OGG1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | OGG1 |
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Synonyms | MMH, MUTM, OGH1 |
Function | DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. |
Cellular Location | Nucleus, nucleoplasm. Nucleus speckle. Nucleus matrix. Note=Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells [Isoform 2A]: Mitochondrion. |
Tissue Location | Ubiquitous. |
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Provided below are standard protocols that you may find useful for product applications.
Background
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3' to the lesion.
References
Aburatani H.,et al.Cancer Res. 57:2151-2156(1997).
Rosenquist T.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:7429-7434(1997).
Roldan-Arjona T.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:8016-8020(1997).
Radicella J.P.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:8010-8015(1997).
Lu R.,et al.Curr. Biol. 7:397-407(1997).
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