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S100A4 / FSP1 Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P26447 |
| Reactivity | Human, Rabbit, Pig, Bovine, Dog, Horse |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 12kDa |
| Dilution | ELISA (1:128000), IHC-P (2.5-5 µg/ml), WB (0.03-0.1 µg/ml) |
| Gene ID | 6275 |
|---|---|
| Other Names | Protein S100-A4, Calvasculin, Metastasin, Placental calcium-binding protein, Protein Mts1, S100 calcium-binding protein A4, S100A4, CAPL, MTS1 |
| Target/Specificity | Human S100A4 / FSP1. Both variants (NP_002952.1; NP_062427.1) represent identical protein. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | S100A4 / FSP1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | S100A4 |
|---|---|
| Synonyms | CAPL, MTS1 |
| Function | Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy (PubMed:16707441, PubMed:23752197, PubMed:30713770). Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (PubMed:16707441). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity). Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (PubMed:23752197). Within the extracellular space, stimulates cytokine production including granulocyte colony- stimulating factor and CCL24 from T-lymphocytes (By similarity). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (PubMed:26654597, PubMed:30713770). |
| Cellular Location | Secreted. Nucleus Cytoplasm {ECO:0000250|UniProtKB:P07091} |
| Tissue Location | Ubiquitously expressed. |
| Volume | Array |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
Engelkamp D.,et al.Biochemistry 31:10258-10264(1992).
Engelkamp D.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:6547-6551(1993).
Tulchinsky E.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:9146-9150(1992).
Ebert L.,et al.Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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