PRX-1 / PRRX1 Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | P54821 |
Reactivity | Human, Mouse, Rat, Rabbit, Hamster, Pig, Chicken, Horse, Bovine, Dog |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 27kDa |
Dilution | ELISA (1:4000), IHC-P (5 µg/ml), WB (1-3 µg/ml) |
Gene ID | 5396 |
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Other Names | Paired mesoderm homeobox protein 1, Homeobox protein PHOX1, Paired-related homeobox protein 1, PRX-1, PRRX1, PMX1 |
Target/Specificity | Human PRRX1. This antibody is expected to recognise both reported isoforms (NP_008833.1; NP_073207.1). |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | PRX-1 / PRRX1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PRRX1 |
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Synonyms | PMX1 |
Function | Master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-enhancer landscape. Through this function, plays an essential role in wound healing process (PubMed:35589735). Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity). May play a role in homeostasis and regeneration of bone, white adipose tissue and derm (By similarity). |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:P63013}. |
Tissue Location | [Isoform 1]: Widely expressed in embryonic and adult tissues, with highest levels in skeletal muscle. Isoform 1 is either expressed at similar or higher levels compared to isoform 2 in all embryonic tissues but skeletal muscle and heart. In adult tissues, expressed at lower levels compared to isoform 2 |
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Provided below are standard protocols that you may find useful for product applications.
Background
Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity).
References
Goshima N.,et al.Nat. Methods 5:1011-1017(2008).
Gregory S.G.,et al.Nature 441:315-321(2006).
Grueneberg D.A.,et al.Science 257:1089-1095(1992).
Sergi C.,et al.Clin. Genet. 79:293-295(2011).
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