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HTR1D / 5-HT1D Receptor Antibody (aa1-18)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P28221 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 42kDa |
| Dilution | IHC-P (10 µg/ml), WB (2 µg/ml), |
| Gene ID | 3352 |
|---|---|
| Other Names | 5-hydroxytryptamine receptor 1D, 5-HT-1D, 5-HT1D, Serotonin 1D alpha receptor, 5-HT-1D-alpha, Serotonin receptor 1D, HTR1D, HTR1DA, HTRL |
| Target/Specificity | A mixture of synthetic peptides corresponding to amino acids 1-18 and 251-267 of rat 5-HT1DR (Genbank accession no. NP_036984). |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | HTR1D / 5-HT1D Receptor Antibody (aa1-18) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HTR1D (HGNC:5289) |
|---|---|
| Synonyms | HTR1DA, HTRL |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731). HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (PubMed:33762731). Regulates the release of 5- hydroxytryptamine in the brain, and thereby affects neural activity (PubMed:18476671, PubMed:20945968). May also play a role in regulating the release of other neurotransmitters (PubMed:18476671, PubMed:20945968). May play a role in vasoconstriction (PubMed:18476671, PubMed:20945968). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Detected in brain neocortex and caudate nucleus (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.
References
Hamblin M.W.,et al.Mol. Pharmacol. 40:143-148(1991).
Weinshank R.L.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:3630-3634(1992).
Puhl H.L. III,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
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