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> home > Products > Primary Antibodies > Antibody Collections > Immunity > ICOSLG / ICOSL / ICOS Ligand Antibody (clone 2D3)
ICOSLG / ICOSL / ICOS Ligand Antibody (clone 2D3)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| IHC-P, FC |
|---|---|
| Primary Accession | O75144 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 2D3 |
| Calculated MW | 33349 Da |
| Dilution | Flo (0.5 µg/10E6 cells), IHC-P (1:50), |
| Gene ID | 23308 |
|---|---|
| Other Names | ICOS ligand, B7 homolog 2, B7-H2, B7-like protein Gl50, B7-related protein 1, B7RP-1, CD275, ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653 |
| Target/Specificity | Human ICOSL/CD275/B7H2 |
| Reconstitution & Storage | +4°C. Store undiluted. |
| Precautions | ICOSLG / ICOSL / ICOS Ligand Antibody (clone 2D3) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ICOSLG |
|---|---|
| Function | Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion (PubMed:11007762, PubMed:11023515, PubMed:30498080). Also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity). In endothelial cells, required for proper neutrophil transmigration in response to chemoattractants, such as CXCL8/IL8 or N-formyl-methionyl peptides (fMLP) (PubMed:30498080). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Expressed on peripheral blood B-cells and monocytes, as well as on monocyte-derived dendritic cells (at protein level). [Isoform 2]: Detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 467.50
Cat# ALS12053
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