CD59 Antibody (clone MEM-43)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, IP, FC |
---|---|
Primary Accession | P13987 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | MEM-43 |
Calculated MW | 14kDa |
Dilution | IHC-P (10 µg/ml) |
Gene ID | 966 |
---|---|
Other Names | CD59 glycoprotein, 1F5 antigen, 20 kDa homologous restriction factor, HRF-20, HRF20, MAC-inhibitory protein, MAC-IP, MEM43 antigen, Membrane attack complex inhibition factor, MACIF, Membrane inhibitor of reactive lysis, MIRL, Protectin, CD59, CD59, MIC11, MIN1, MIN2, MIN3, MSK21 |
Target/Specificity | Thymocytes and T lymphocytes |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Precautions | CD59 Antibody (clone MEM-43) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CD59 |
---|---|
Synonyms | MIC11, MIN1, MIN2, MIN3, MSK21 |
Function | Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. |
Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Soluble form found in a number of tissues |
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Background
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
References
Davies A.,et al.J. Exp. Med. 170:637-654(1989).
Philbrick W.M.,et al.Eur. J. Immunol. 20:87-92(1990).
Okada H.,et al.Biochem. Biophys. Res. Commun. 162:1553-1559(1989).
Sugita Y.,et al.J. Biochem. 106:555-557(1989).
Sawada R.,et al.DNA Cell Biol. 9:213-220(1990).
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