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IFN Beta / Interferon Beta Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P01574 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 22kDa |
| Dilution | IHC-P (5 µg/ml), WB (5 µg/ml), |
| Gene ID | 3456 |
|---|---|
| Other Names | Interferon beta, IFN-beta, Fibroblast interferon, IFNB1, IFB, IFNB |
| Target/Specificity | an 17 amino acid peptide from near the center of human IFN-b |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | IFN Beta / Interferon Beta Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IFNB1 (HGNC:5434) |
|---|---|
| Synonyms | IFB, IFNB |
| Function | Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli (PubMed:10049744, PubMed:10556041, PubMed:6157094, PubMed:6171735, PubMed:7665574, PubMed:8027027, PubMed:8969169). Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (PubMed:10049744, PubMed:10556041, PubMed:7665574, PubMed:8027027, PubMed:8969169). Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways (By similarity). Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)- inducible production of tumor necrosis factor (By similarity). Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss (By similarity). IFNB1 is more potent than interferon-alpha (IFN- alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity). |
| Cellular Location | Secreted. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Has antiviral, antibacterial and anticancer activities.
References
Lawn R.M.,et al.Nucleic Acids Res. 9:1045-1052(1981).
Ohno S.,et al.Proc. Natl. Acad. Sci. U.S.A. 78:5305-5309(1981).
Taniguchi T.,et al.Gene 10:11-15(1980).
Derynck R.,et al.Nature 285:542-547(1980).
Houghton M.,et al.Nucleic Acids Res. 8:2885-2894(1980).
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