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SOCS4 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IP |
|---|---|
| Primary Accession | Q8WXH5 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 51kDa |
| Dilution | IHC-P (10 µg/ml), IP (0.3-0.5 µg/10E6 cells), WB (0.5-2 µg/ml) |
| Gene ID | 122809 |
|---|---|
| Other Names | Suppressor of cytokine signaling 4, SOCS-4, Suppressor of cytokine signaling 7, SOCS-7, SOCS4, SOCS7 |
| Target/Specificity | Peptide from the C-terminus of human SOCS4 |
| Reconstitution & Storage | +4°C, avoid freezing |
| Precautions | SOCS4 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SOCS4 |
|---|---|
| Synonyms | SOCS7 |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR. |
| Volume | 250 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.
References
Hilton D.J.,et al.Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
Kario E.,et al.J. Biol. Chem. 280:7038-7048(2005).
Bullock A.N.,et al.Structure 15:1493-1504(2007).
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