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CIDEA / CIDE-A Antibody (aa200-217)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF |
|---|---|
| Primary Accession | O60543 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 25kDa |
| Dilution | IHC-P (10 µg/ml), WB (1:1000-1:2000), |
| Gene ID | 1149 |
|---|---|
| Other Names | Cell death activator CIDE-A, Cell death-inducing DFFA-like effector A, CIDEA |
| Target/Specificity | peptide corresponding to amino acids 200 to 217 of human CIDE-A |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | CIDEA / CIDE-A Antibody (aa200-217) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CIDEA {ECO:0000303|PubMed:18509062, ECO:0000312|HGNC:HGNC:1976} |
|---|---|
| Function | Lipid transferase that promotes unilocular lipid droplet formation by mediating lipid droplet fusion (PubMed:19843876, PubMed:26118629). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (PubMed:19843876). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (By similarity). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC (By similarity). May also act as a CEBPB coactivator in epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein (By similarity). By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). When overexpressed, induces apoptosis; the physiological significance of its role in apoptosis is unclear (By similarity). |
| Cellular Location | Lipid droplet. Nucleus {ECO:0000250|UniProtKB:O70302}. Note=Enriched at lipid droplet contact sites. |
| Tissue Location | Expressed in omental and subcutaneous adipose tissue (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear.
References
Inohara N.,et al.EMBO J. 17:2526-2533(1998).
Liang L.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Puri V.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:7833-7838(2008).
Liu K.,et al.Am. J. Physiol. 297:E1395-E1413(2009).
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