TNFSF10 / TRAIL Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, ICC, IHC-F, FC |
---|---|
Primary Accession | P50591 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 33kDa |
Dilution | ICC, IHC-P (5 µg/ml), |
Gene ID | 8743 |
---|---|
Other Names | Tumor necrosis factor ligand superfamily member 10, Apo-2 ligand, Apo-2L, TNF-related apoptosis-inducing ligand, Protein TRAIL, CD253, TNFSF10, APO2L, TRAIL |
Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
Precautions | TNFSF10 / TRAIL Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TNFSF10 |
---|---|
Synonyms | APO2L, TRAIL |
Function | Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:10549288, PubMed:26457518). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. |
Cellular Location | Cell membrane; Single-pass type II membrane protein. Secreted. Note=Exists both as membrane-bound and soluble form. |
Tissue Location | Widespread; most predominant in spleen, lung and prostate |
Volume | 100 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
References
Wiley S.R.,et al.Immunity 3:673-682(1995).
Pitti R.M.,et al.J. Biol. Chem. 271:12687-12690(1996).
Schnepple D.J.,et al.J. Biol. Chem. 286:35742-35754(2011).
Woods D.C.,et al.Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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