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LPP3 / PPAP2B Antibody

Rabbit Polyclonal Antibody

     
  • IHC - LPP3 / PPAP2B Antibody ALS11511
    Anti-PPAP2B antibody IHC of human placenta.
    detail
  • SPECIFICATION
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession O14495
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 35kDa
Dilution IHC-P (20 µg/ml)
Additional Information
Gene ID 8613
Other Names Lipid phosphate phosphohydrolase 3, 3.1.3.4, PAP2-beta, Phosphatidate phosphohydrolase type 2b, Phosphatidic acid phosphatase 2b, PAP-2b, PAP2b, Vascular endothelial growth factor and type I collagen-inducible protein, VCIP, PPAP2B, LPP3
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsLPP3 / PPAP2B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLPP3 (HGNC:9229)
Synonyms LPP3, PPAP2B
Function Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P (PubMed:27694435, PubMed:9607309, PubMed:9705349). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)- ethanolamine phosphate, a potential physiological compound (PubMed:9607309). Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (PubMed:23591818, PubMed:27694435, PubMed:9607309). Through the dephosphorylation of extracellular sphingosine-1-phosphate and the regulation of its extra- and intracellular availability, plays a role in vascular homeostasis, regulating endothelial cell migration, adhesion, survival, proliferation and the production of pro-inflammatory cytokines (PubMed:27694435). By maintaining the appropriate levels of this lipid in the cerebellum, also ensure its proper development and function (By similarity). Through its intracellular lipid phosphatase activity may act in early compartments of the secretory pathway, regulating the formation of Golgi to endoplasmic reticulum retrograde transport carriers (PubMed:23591818).
Cellular Location Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Basolateral cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi- pass membrane protein {ECO:0000250|UniProtKB:P97544}. Golgi apparatus membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Membrane raft; Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Note=Cycles between the endoplasmic reticulum and the Golgi.
Tissue Location Ubiquitously expressed (PubMed:12660161, PubMed:9305923). Highly expressed in heart and placenta (PubMed:9305923).
Research Areas
Citations (0)
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Background

Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions.

References

Kai M.,et al.J. Biol. Chem. 272:24572-24578(1997).
Roberts R.,et al.J. Biol. Chem. 273:22059-22067(1998).
Humtsoe J.O.,et al.EMBO J. 22:1539-1554(2003).
Leung D.W.,et al.Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
Yu W.,et al.Genome Res. 7:353-358(1997).

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$ 467.50
Cat# ALS11511
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