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TP1 / TEP1 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF |
|---|---|
| Primary Accession | Q99973 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 290kDa |
| Dilution | IHC-P (5 µg/ml) |
| Gene ID | 7011 |
|---|---|
| Other Names | Telomerase protein component 1, Telomerase-associated protein 1, Telomerase protein 1, p240, p80 telomerase homolog, TEP1, TLP1, TP1 |
| Target/Specificity | 20 amino acid peptide from near the amino terminus of human TP1. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | TP1 / TEP1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TEP1 |
|---|---|
| Synonyms | TLP1, TP1 |
| Function | Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini (PubMed:19179534). Also a component of the ribonucleoprotein vaults particle, a multi- subunit structure involved in nucleo-cytoplasmic transport (By similarity). Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity). |
| Cellular Location | Nucleus. Chromosome, telomere. |
| Tissue Location | Ubiquitous.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi- subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity).
References
Harrington L.,et al.Science 275:973-977(1997).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Harrington L.,et al.Genes Dev. 11:3109-3115(1997).
Kickhoefer V.A.,et al.J. Biol. Chem. 274:32712-32717(1999).
Beattie T.L.,et al.Mol. Biol. Cell 11:3329-3340(2000).
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