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PPP1R13L / iASPP Antibody (aa780-797)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q8WUF5 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 89kDa |
| Dilution | ELISA (1:40000-1:160000), IHC-P (2.5 µg/ml), WB (1:1000-1:5000) |
| Gene ID | 10848 |
|---|---|
| Other Names | RelA-associated inhibitor, Inhibitor of ASPP protein, Protein iASPP, NFkB-interacting protein 1, PPP1R13B-like protein, PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI |
| Target/Specificity | Amino acids 780-797 of human iASPP (isoform 1) protein. |
| Reconstitution & Storage | Store vial at -20 C prior to opening. Dilute only prior to immediate use. For extended storage aliquot contents and freeze at -20 C or below. Avoid cycles of freezing and thawing. |
| Precautions | PPP1R13L / iASPP Antibody (aa780-797) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PPP1R13L |
|---|---|
| Synonyms | IASPP, NKIP1, PPP1R13BL, RAI |
| Function | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). |
| Cellular Location | Cytoplasm. Nucleus Note=Predominantly cytoplasmic but also nuclear |
| Tissue Location | Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.
References
Slee E.A.,et al.Oncogene 23:9007-9016(2004).
Herron B.J.,et al.Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
Yang J.-P.,et al.J. Biol. Chem. 274:15662-15670(1999).
Takada N.,et al.J. Virol. 76:8019-8030(2002).
Bergamaschi D.,et al.Nat. Genet. 33:162-167(2003).
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