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PPP1R13L / iASPP Antibody (aa780-797)

Rabbit Polyclonal Antibody

     
  • IHC - PPP1R13L / iASPP Antibody (aa780-797) ALS11346
    Anti-PPP1R13L / IASPP antibody IHC of human liver.
    detail
  • WB - PPP1R13L / iASPP Antibody (aa780-797) ALS11346
    Anti-iASPP Antibody - Western Blot.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q8WUF5
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 89kDa
Dilution ELISA (1:40000-1:160000), IHC-P (2.5 µg/ml), WB (1:1000-1:5000)
Additional Information
Gene ID 10848
Other Names RelA-associated inhibitor, Inhibitor of ASPP protein, Protein iASPP, NFkB-interacting protein 1, PPP1R13B-like protein, PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Target/Specificity Amino acids 780-797 of human iASPP (isoform 1) protein.
Reconstitution & Storage Store vial at -20 C prior to opening. Dilute only prior to immediate use. For extended storage aliquot contents and freeze at -20 C or below. Avoid cycles of freezing and thawing.
PrecautionsPPP1R13L / iASPP Antibody (aa780-797) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPP1R13L
Synonyms IASPP, NKIP1, PPP1R13BL, RAI
Function Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640).
Cellular Location Cytoplasm. Nucleus Note=Predominantly cytoplasmic but also nuclear
Tissue Location Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte.
Research Areas
Citations (0)
citation

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Background

Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.

References

Slee E.A.,et al.Oncogene 23:9007-9016(2004).
Herron B.J.,et al.Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
Yang J.-P.,et al.J. Biol. Chem. 274:15662-15670(1999).
Takada N.,et al.J. Virol. 76:8019-8030(2002).
Bergamaschi D.,et al.Nat. Genet. 33:162-167(2003).

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$ 467.50
Cat# ALS11346
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