PPARG / PPAR Gamma Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, IHC-P, E |
---|---|
Primary Accession | P37231 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 58kDa |
Dilution | ELISA (1:3200-1:10000), IHC-P (2.5 µg/ml), WB (1:1000-1:3000) |
Gene ID | 5468 |
---|---|
Other Names | Peroxisome proliferator-activated receptor gamma, PPAR-gamma, Nuclear receptor subfamily 1 group C member 3, PPARG, NR1C3 |
Target/Specificity | A region near the amino terminus of human PPAR gamma 2. |
Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
Precautions | PPARG / PPAR Gamma Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PPARG |
---|---|
Synonyms | NR1C3 |
Function | Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels (By similarity). |
Cellular Location | Nucleus. Cytoplasm. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. NOCT enhances its nuclear translocation |
Tissue Location | Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary. |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).
References
Mukherjee R.,et al.J. Biol. Chem. 272:8071-8076(1997).
Elbrecht A.,et al.Biochem. Biophys. Res. Commun. 224:431-437(1996).
Yanase T.,et al.Biochem. Biophys. Res. Commun. 233:320-324(1997).
Greene M.E.,et al.Gene Expr. 4:281-299(1995).
Greene M.E.,et al.Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
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