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IAPP / Amylin Antibody (clone R10/99)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IF, IHC-F |
|---|---|
| Primary Accession | P10997 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | R10/99 |
| Calculated MW | 10kDa |
| Dilution | IHC-Fr, IHC-P (1:100), |
| Gene ID | 3375 |
|---|---|
| Other Names | Islet amyloid polypeptide, Amylin, Diabetes-associated peptide, DAP, Insulinoma amyloid peptide, IAPP |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | IAPP / Amylin Antibody (clone R10/99) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IAPP (HGNC:5329) |
|---|---|
| Function | Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis (PubMed:2690069). Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR- RAMPs (AMYRs) receptor complexes (By similarity). Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs (By similarity). |
| Cellular Location | Secreted. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
References
Mosselman S.,et al.FEBS Lett. 247:154-158(1989).
Nishi M.,et al.Mol. Endocrinol. 3:1775-1781(1989).
Sanke T.,et al.J. Biol. Chem. 263:17243-17246(1988).
Christmanson L.,et al.FEBS Lett. 267:160-166(1990).
van Mansfeld A.D.M.,et al.Biochim. Biophys. Acta 1087:235-240(1990).
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