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Aspartate Aminotransferase Antibody
Sheep Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, IP |
|---|---|
| Primary Accession | P17174 |
| Reactivity | Human, Pig |
| Host | Sheep |
| Clonality | Polyclonal |
| Calculated MW | 46kDa |
| Dilution | IHC-P (20 µg/ml) |
| Gene ID | 2805 |
|---|---|
| Other Names | Aspartate aminotransferase, cytoplasmic, cAspAT, 2.6.1.1, 2.6.1.3, Cysteine aminotransferase, cytoplasmic, Cysteine transaminase, cytoplasmic, cCAT, Glutamate oxaloacetate transaminase 1, Transaminase A, GOT1 |
| Target/Specificity | Aspartate Transaminase |
| Reconstitution & Storage | Long term: -20°C; Short term: -20°C |
| Precautions | Aspartate Aminotransferase Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GOT1 (HGNC:4432) |
|---|---|
| Function | Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2- aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456). |
| Cellular Location | Cytoplasm. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
References
Bousquet-Lemercier B.,et al.Biochemistry 29:5293-5299(1990).
Wang C.Y.,et al.Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
Yu W.,et al.Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 429:375-381(2004).
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