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TM9SF4 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q92544 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 75kDa |
| Dilution | IHC-P (5 µg/ml) |
| Gene ID | 9777 |
|---|---|
| Other Names | Transmembrane 9 superfamily member 4, TM9SF4, KIAA0255 |
| Target/Specificity | Human TM9SF4. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | TM9SF4 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TM9SF4 |
|---|---|
| Synonyms | KIAA0255, TUCAP1 {ECO:0000303|PubMed:198 |
| Function | Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface (PubMed:25999474). Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells (PubMed:25659576). Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells (PubMed:19893578). |
| Cellular Location | Membrane; Multi-pass membrane protein. Golgi apparatus Early endosome |
| Tissue Location | Highly expressed in metastatic melanoma cells whereas it is undetectable in primary melanoma cells, healthy skin tissues and peripheral blood lymphocytes. Expressed in CD34(+) hematopoietic progenitor cells and during monocyte and granulocyte differentiation. Overexpressed in acute myeloid leukemia, in particular in those displaying granulocytic differentiation (at protein level) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Nagase T.,et al.DNA Res. 3:321-329(1996).
Deloukas P.,et al.Nature 414:865-871(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Zahedi R.P.,et al.J. Proteome Res. 7:526-534(2008).
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