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PIGR Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P01833 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 83kDa |
| Dilution | IHC-P (1.25-2.5 µg/ml) |
| Gene ID | 5284 |
|---|---|
| Other Names | Polymeric immunoglobulin receptor, PIgR, Poly-Ig receptor, Hepatocellular carcinoma-associated protein TB6, Secretory component, PIGR |
| Target/Specificity | Human PIGR. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | PIGR Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PIGR |
|---|---|
| Function | [Polymeric immunoglobulin receptor]: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. |
| Cellular Location | [Polymeric immunoglobulin receptor]: Cell membrane; Single-pass type I membrane protein |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
References
Krajci P.,et al.Hum. Genet. 87:642-648(1991).
Krajci P.,et al.Eur. J. Immunol. 22:2309-2315(1992).
Dong X.,et al.Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Krajci P.,et al.Biochem. Biophys. Res. Commun. 158:783-789(1989).
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