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WNT4 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - WNT4 Antibody (Internal) ALS11136
    Anti-WNT4 antibody ALS11136 IHC of human thyroid.
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  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P56705
Reactivity Human, Mouse, Hamster, Monkey, Pig, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 39kDa
Dilution IHC-P (10-15 µg/ml)
Additional Information
Gene ID 54361
Other Names Protein Wnt-4, WNT4
Target/Specificity Human WNT4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsWNT4 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name WNT4
Function Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in the embryonic development of the urogenital tract and the lung (PubMed:15317892, PubMed:16959810, PubMed:18179883, PubMed:18182450). Required for normal mesenchyme to epithelium transition during embryonic kidney development. Required for the formation of early epithelial renal vesicles during kidney development (By similarity). Required for normal formation of the Mullerian duct in females, and normal levels of oocytes in the ovaries (PubMed:15317892, PubMed:16959810, PubMed:18182450). Required for normal down-regulation of 3 beta-hydroxysteroid dehydrogenase in the ovary (PubMed:15317892, PubMed:16959810, PubMed:18182450). Required for normal lung development and for normal patterning of trachael cartilage rings (By similarity).
Cellular Location Secreted, extracellular space, extracellular matrix
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue.

References

Testa T.T.,et al.Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
Jordan B.K.,et al.Am. J. Hum. Genet. 68:1102-1109(2001).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.

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$ 467.50
Cat# ALS11136
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