WNT1 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| IHC-P |
---|---|
Primary Accession | P04628 |
Reactivity | Human, Mouse, Rabbit, Hamster, Monkey, Pig, Horse, Bovine, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 41kDa |
Dilution | IHC-P (5 µg/ml) |
Gene ID | 7471 |
---|---|
Other Names | Proto-oncogene Wnt-1, Proto-oncogene Int-1 homolog, WNT1, INT1 |
Target/Specificity | Human WNT1. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
Precautions | WNT1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | WNT1 |
---|---|
Synonyms | INT1 |
Function | Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (PubMed:23499309, PubMed:23656646, PubMed:26902720, PubMed:28528193). In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling (By similarity). Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (By similarity). Has a role in osteoblast function, bone development and bone homeostasis (PubMed:23499309, PubMed:23656646). |
Cellular Location | Secreted, extracellular space, extracellular matrix. Secreted |
Volume | 50 µl |

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Background
Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Has a role in osteoblast function and bone development.
References
van Ooyen A.,et al.EMBO J. 4:2905-2909(1985).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Doubravska L.,et al.Cell. Signal. 23:837-848(2011).
Keupp K.,et al.Am. J. Hum. Genet. 92:565-574(2013).

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