ABCB1 / MDR1 / P Glycoprotein Antibody (Cytoplasmic Domain)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| IHC-P |
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Primary Accession | P08183 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 141kDa |
Dilution | IHC-P (20 µg/ml) |
Gene ID | 5243 |
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Other Names | Multidrug resistance protein 1, 3.6.3.44, ATP-binding cassette sub-family B member 1, P-glycoprotein 1, CD243, ABCB1, MDR1, PGY1 |
Target/Specificity | Human ABCB1 / MDR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
Precautions | ABCB1 / MDR1 / P Glycoprotein Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ABCB1 (HGNC:40) |
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Synonyms | MDR1, PGY1 |
Function | Translocates drugs and phospholipids across the membrane (PubMed:2897240, PubMed:35970996, PubMed:8898203, PubMed:9038218, PubMed:35507548). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:35970996, PubMed:9038218). |
Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441} Apical cell membrane. Cytoplasm Note=ABCB1 localization is influenced by C1orf115 expression levels (plasma membrane versus cytoplasm). Localized to the apical membrane of enterocytes (PubMed:28408210). |
Tissue Location | Expressed in small intestine (PubMed:28408210). Expressed in liver, kidney and brain. |
Volume | 100 µl |

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Provided below are standard protocols that you may find useful for product applications.
Background
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
References
Chen C.-J.,et al.Cell 47:381-389(1986).
Chen C.-J.,et al.J. Biol. Chem. 265:506-514(1990).
Chen G.,et al.J. Biol. Chem. 272:5974-5982(1997).
Jiang Y.,et al.Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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