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SLC11A2 / DMT1 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - SLC11A2 / DMT1 Antibody (C-Terminus) ALS11085
    Anti-SLC11A2 antibody ALS11085 IHC of human pancreas.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P49281
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 62kDa
Dilution IHC-P (15 µg/ml)
Additional Information
Gene ID 4891
Other Names Natural resistance-associated macrophage protein 2, NRAMP 2, Divalent cation transporter 1, Divalent metal transporter 1, DMT-1, Solute carrier family 11 member 2, SLC11A2, DCT1, DMT1, NRAMP2
Target/Specificity Human SLC11A2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsSLC11A2 / DMT1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC11A2
Synonyms DCT1, DMT1, NRAMP2
Function Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1 (PubMed:17109629, PubMed:17293870, PubMed:22736759, PubMed:25326704, PubMed:25491917). Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+) (PubMed:17109629, PubMed:17293870, PubMed:22736759, PubMed:25326704, PubMed:25491917). Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells (By similarity). Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense (By similarity) (PubMed:24448823). Can mediate uncoupled fluxes of either protons or metal ions.
Cellular Location [Isoform 1]: Early endosome membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Predominantly localizes in early endosomes that underlie the apical membrane of polarized epithelia. [Isoform 3]: Cell membrane
Tissue Location Ubiquitously expressed. Expressed in erythroid progenitors.
Volume 50 µl
Research Areas
Citations (0)
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Background

Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria.

References

Kishi F.,et al.Mol. Immunol. 34:839-842(1997).
Kishi F.,et al.Biochem. Biophys. Res. Commun. 251:775-783(1998).
Lee P.L.,et al.Blood Cells Mol. Dis. 24:199-215(1998).
Hubert N.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:12345-12350(2002).
Worthington M.T.,et al.Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.

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$ 467.50
Cat# ALS11085
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