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SLC12A2 / NKCC1 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P55011 |
| Reactivity | Human, Mouse, Hamster, Monkey, Pig, Horse, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 131kDa |
| Dilution | IHC-P (5-10 µg/ml) |
| Gene ID | 6558 |
|---|---|
| Other Names | Solute carrier family 12 member 2, Basolateral Na-K-Cl symporter, Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1, SLC12A2, NKCC1 |
| Target/Specificity | Human SLC12A2 / NKCC1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except CDR2 (41%). |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | SLC12A2 / NKCC1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC12A2 |
|---|---|
| Function | Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714, PubMed:35585053, PubMed:36239040, PubMed:36306358, PubMed:7629105). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105). |
| Cellular Location | Basolateral cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in many tissues. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.
References
Payne J.A.,et al.J. Biol. Chem. 270:17977-17985(1995).
Vibat C.R.,et al.Anal. Biochem. 298:218-230(2001).
Cantin G.T.,et al.J. Proteome Res. 7:1346-1351(2008).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cruz-Rangel S.,et al.Am. J. Physiol. 301:C601-C608(2011).
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