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CD27L / CD70 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - CD27L / CD70 Antibody (Internal) ALS11020
    Anti-CD70 antibody ALS11020 IHC of human tonsil..
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P32970
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 21kDa
Dilution IHC-P (5-10 µg/ml)
Additional Information
Gene ID 970
Other Names CD70 antigen, CD27 ligand, CD27-L, Tumor necrosis factor ligand superfamily member 7, CD70, CD70, CD27L, CD27LG, TNFSF7
Target/Specificity Human CD70. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsCD27L / CD70 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD70 (HGNC:11937)
Function Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells (PubMed:28011863, PubMed:28011864, PubMed:8387892). The CD70- CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells (PubMed:28011863, PubMed:28011864).
Cellular Location Cell membrane; Single-pass type II membrane protein
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.

References

Goodwin R.G.,et al.Cell 73:447-456(1993).
Bowman M.R.,et al.J. Immunol. 152:1756-1761(1994).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Livingston R.J.,et al.Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.

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$ 467.50
Cat# ALS11020
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