TMPRSS4 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | Q9NRS4 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 48kDa |
Dilution | IHC-P (15-20 µg/ml) |
Gene ID | 56649 |
---|---|
Other Names | Transmembrane protease serine 4, 3.4.21.-, Channel-activating protease 2, CAPH2, Membrane-type serine protease 2, MT-SP2, TMPRSS4, TMPRSS3 |
Target/Specificity | Human TMPRSS4. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
Precautions | TMPRSS4 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TMPRSS4 (HGNC:11878) |
---|---|
Function | Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity (PubMed:24434139). Seems to be capable of activating ENaC (By similarity). |
Cellular Location | Cell membrane; Single-pass type II membrane protein |
Tissue Location | High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal gastrointestinal and urogenital tract (PubMed:10825129). Coexpressed with ACE2 within mature enterocytes (PubMed:32404436). |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Probable protease. Seems to be capable of activating ENaC (By similarity).
References
Wallrapp C.,et al.Cancer Res. 60:2602-2606(2000).
Smeekens S.S.,et al.Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Taylor T.D.,et al.Nature 440:497-500(2006).
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