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CDC7 Antibody (Kinase Domain)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | O00311 |
| Reactivity | Human, Rabbit, Horse, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 64kDa |
| Dilution | IHC-P (6.5 µg/ml) |
| Gene ID | 8317 |
|---|---|
| Other Names | Cell division cycle 7-related protein kinase, CDC7-related kinase, HsCdc7, huCdc7, 2.7.11.1, CDC7, CDC7L1 |
| Target/Specificity | Human CDC7. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | CDC7 Antibody (Kinase Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CDC7 (HGNC:1745) |
|---|---|
| Synonyms | CDC7L1 |
| Function | Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN. |
| Cellular Location | Nucleus. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.
References
Sato N.,et al.EMBO J. 16:4340-4351(1997).
Hess G.F.,et al.Gene 211:133-140(1998).
Jiang W.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:14320-14325(1997).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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