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CDK12 / CRKRS Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q9NYV4 |
| Reactivity | Human, Monkey, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 164kDa |
| Dilution | IHC-P (6 µg/ml) |
| Gene ID | 51755 |
|---|---|
| Other Names | Cyclin-dependent kinase 12, 2.7.11.22, 2.7.11.23, Cdc2-related kinase, arginine/serine-rich, CrkRS, Cell division cycle 2-related protein kinase 7, CDC2-related protein kinase 7, Cell division protein kinase 12, hCDK12, CDK12, CRK7, CRKRS, KIAA0904 |
| Target/Specificity | Human CDK12 / CRKRS. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except AKAP12 (55%). |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | CDK12 / CRKRS Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CDK12 |
|---|---|
| Synonyms | CRK7, CRKRS, KIAA0904 |
| Function | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. |
| Cellular Location | Nucleus. Nucleus speckle. Note=Colocalized with nuclear speckles throughout interphase. |
| Tissue Location | Widely expressed.. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
References
Ko T.K.,et al.J. Cell Sci. 114:2591-2603(2001).
Nagase T.,et al.DNA Res. 5:355-364(1998).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
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